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The results showed that loss of GSTA4 significantly decreased cell proliferation and clonogenicity, whereas it increased intracellular reactive oxygen species and cell susceptibility to 5-fluorouracil (5-FU) and oxaliplatin

Regehr WG, Carey MR, Best AR

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28-30 These actions are mainly mediated by 2-adrenergic receptor subtypes 29,31 although other adrenergic-receptor-independent mechanisms, 28 vagomimetic, and humoral pathways contribute to the anti-inflammatory effect