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The derivative demonstrated comprehensive effects on multiple aspects of cardiac metabolism, including enhancement of myocardial ATP synthesis, improvement of calcium handling in cardiomyocytes, and reduction of oxidative stress markers in failing heart tissue
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The increase in off-label use makes it easier for unqualified individuals to obtain it (Turnock et al
BRPF1 contains a bromodomain, which is reported to bind H2AK5ac, H4K12ac, and H3K14ac (Poplawski et al, 2014), and two PHD fingers closely linked by a zinc knuckle, which bind to unmodified histone H3 tail and nucleosomal DNA (Klein et al, 2016)
