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Intracellular trapping of the selective phosphoglycerate dehydrogenase (PHGDH) inhibitor BI-4924 disrupts serine biosynthesis

Although a wide range of cereblon ligands that can be used to construct PROTACs are currently reported, most of cereblon-recruiting PROTACs results from attaching different types of linkers to pomalidomide, thalidomide and lenalidomide derivatives

doi: 10.1016/j.neulet.2015.05.024

[DOI] [PubMed] [Google Scholar] 73.Koch V., Gruenewald L.D., Gruber-Rouh T., Eichler K., Leistner D.M., Mahmoudi S., Booz C., Bernatz S., DAngelo T., Albrecht M.H., et al

Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinsons disease by suppressing gut bacterial tyrosine decarboxylase