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These alterations ultimately cause synaptic dysfunction in AD rat models

The prolonged presence of these cells on at a relatively higher level suggested a still ongoing remyelination process that requires the continuous generation of new OLs and the synthesis of myelin-related proteins for the forming of new compact myelin, although the myelin score by LFB-PAS staining has already returned to a level indistinguishable from the normal control by 3 weeks after CPZ withdrawal

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Chandy thinks the phenomenon occurs because the B12 allows the body to put itself right, and if you have had things wrong for a long time, then theres a lot to put right in a small period of time