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Pollari E, Goldsteins G, Bart G, Koistinaho J, Giniatullin R

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Under certain conditions, GGT-mediated degradation of GSH facilitates the formation of reactive oxygen species, causing lipid peroxidation of cell membranes, which ultimately leads to apoptosis or necrosis of gastric epithelial cells in vitro 15

Vesicle nucleation requires PI3K-III and Beclin-1 activation, along with additional factors recruiting proteins and lipids to form the autophagosome

Splitting these disulfide bonds is accompanied by loss of biologic activity of the binding protein and can prevent viral replication [76]