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In addition, the trigeminal nerve, which innervates both the respiratory and olfactory regions, provides a direct anatomical pathway from the nasal cavity to the brainstem and olfactory bulb (Johnson et al., 2010)

Theoretically, this may lead to headaches and migraine due to blood pressure changes in your brains small blood vessels

Safe for Long-Term Use : Oral supplements are generally safe for long-term use and can be taken on a daily basis to maintain adequate levels of vitamin B12

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(But again, these are animal studies, so theres no evidence that the benefits would translate to humans.) Glycine also has an impact on the nervous system, which may help with calming down the body and leading to deeper REM sleep