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ROS induce oxidative dimerization of the HIF prolyl hydroxylase, leading to its inactivation and HIF stabilization [52]

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Bugge E., Wynn R., Mollnes T.E., Reitan S.K., Grnli O.K

This does not necessarily increase therapeutic benefit proportionally because tissue binding sites saturate

It applies easily with no residue, while providing hydration and antioxidant protection

A systematic review of guidelines for managing rheumatoid arthritis
