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There is not much information available on the bioavailability of coffee melanoidin antioxidants, and melanoidins have low digestibility

This review presents our current understanding about the status of glutathione and its role as an exogenously added molecule in food grade LAB and closely related organisms.

Here's a snappy breakdown of what it looks like: Chronic Illness Glutathione Status Ulcerative Colitis On the low side Crohn's Disease Down in the dumps Type 2 Diabetes (complications included) Low as well Keeping our glutathione topped up might be a smart move in dodging or handeling these health niggles