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In addition, it has been reported that a decreased expression of p62/SQSM1 significantly decreases ERK phosphorylation, attenuating the proliferation and invasion of glioma cells induce by Guanylate binding proteins-3 (GBP) in vitro [135]

[ 180 , 181 ] Additionally, genetic variations in the BACH2 locus have been linked with a higher risk of autoimmune and allergic diseases, [ 182 , 183 ] future work is needed to elucidate the specific roles of BACH proteins in human immunity

GSTT1 -positive carriers display higher GST activity and may exhibit relative protection against oxidative stress and oxidative DNA damage (39)

Pharmacokinetics studies showed that IN delivery of Cyclosporine-A nanoemulsion has a significantly higher brain-to-blood concentration ratio and lower systemic tissue distribution compared with IV injection route (Yadav et al., 2015)

Structurally, the synthetic fragment retains the active signaling properties of the parent molecule