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392 They further studied another breast cancer cell line of BT474, and found apigenin can also effectively inhibit its proliferation in a dose- and time-dependent manner through downregulating the expression of p-JAK1, p-JAK2, and p-STAT3 and decreasing the production of STAT3 target genes such as VEGF and MMP-9 to prevent or treat HER-2-overexpressing breast cancer

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Kwitny, S., Klaus, A

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