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M2 macrophages possess a weak antigen-presenting ability, and secrete anti-inflammatory cytokines such as IL-10 or TGF-, and down-regulate the immune response [88,89,90].Tumor-associated macrophages (TAMs) have been shown to be functionally plastic as a special type of macrophage, which are often described as M2-like population, but there is also evidence for the existence of M1-like population [91,92,93].In fact, in the early phase of tumor establishment, TAMs display an inflammatory phenotype, but an immunosuppressive phenotype is present at the later stages of tumor progression [94]

Parkinsons disease, or PD, is a neurodegenerative disorder of the central nervous system

In adult humans, Arg synthesis primarily occurs through the intestinal-renal axis, where small intestinal enterocytes, expressing carbamoyl phosphate synthetase I (CPS1) and ornithine transcarbamylase (OTC), convert dietary Glu, Pro, or ornithine into citrulline (CIT) (Marini et al

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Jabbari A, Dai Z, Xing L, Cerise J, Ramot Y, Berkun Y, Sanchez G, Goldbach-Mansky R, Christiano A, Clynes R, Zlotogorski A (2015) Reversal of alopecia areata following treatment with the JAK1/2 inhibitor baricitinib