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Description
The NCI SEER CanMED database classifies J1453 under the major drug class Antiemetic, minor class Substance P/Neurokinin 1, with an FDA approval year of 2008
Even with the gold standard, there are questions as to what the degree of change (infiltration with inflammatory cells) exceeds normal wear-and-tear of day-to-day life
While hydroxocobalamin is not already methylated, it is readily converted to this form to support the methylation cycle
Adults usually start with a 1000 mcg dose daily for a week
Yoshino J, et al
