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Front Immunol (2022) 13:916664

In patients with PCOS, the increased production of gamma-aminobutyric acid (GABA) by gut bacteria is associated with elevated levels of LH and an increased LH/ FSH ratio, indicating that the gut-brain-gonadal axis may play a critical role in menstrual irregularities (89)

And phase one trials are done at the nih

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We mean this sincerely: if a protocol doesn't explain why timing matters at the enzyme level, it's speculation dressed up as expertise
