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To illustrate, these toxins included industrial chemicals, heavy metals, polychlorinated biphenyls (PCBs), insecticides, dioxin, and benzene

37,38 In the healthy lung, proteases are counterbalanced by antiproteases, but the balance shifts toward proteases when cigarette smoke or other pollutants recruit neutrophils and macrophages able to produce overwhelming proteases and induce destruction of healthy lung parenchyma

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In contrast, due to the vertical distribution of the *OOH intermediate at the Ru site on Ru-oxide, the H atom on *OOH is unfavorable for the interaction with the Ru site, resulting in unfavorable decomposition of *OOH on Ru-oxide (Fig