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These include capsaicin (the active pungent component in chillies), consumption of pungent and spicy foods, alcohol, and pan (betel leaf often combined with tobacco powder and slaked lime)

10.1016/S1474-4422(24)00038-3 62 GerhardssonL

pyrrolidine dithiocarbamate (PDTC) (230), flavonoids (237241), melatonin (242), capsaicin (243), sulforaphane (244247), oxymatrine (248), rFGF21 (205, 206), MSCs (249, 250), vardenafil (224), MCC950 (225) and trimetazidine (251)]

Lastly, the duration of the intervention in ANSWER was 17.6 months versus 63 days in MACHT, suggesting that the response is not only dose-dependent, but also time-dependent
