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The Classic Case of Confounding Variables This is, by far, the most common reason for the myth's existence

Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

10.1016/j.tox.2005.05.010 102

Ying, Y., Tao, N., Zhang, F., Wen, X., Zhou, M., & Gao, J
The first-line test is serum vitamin B12 measurement , with levels below 148 pmol/L generally considered deficient, though the exact threshold varies between laboratories