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doi: 10.1002/advs.201701043

For individuals following a plant-based or vegetarian diet, B12 IM injections may be a preferred method of supplementation, as plant foods do not naturally contain significant amounts of B12

Treatment of this patient was effected by oral administration of creatine monohydrate

AOX, Alternative oxidase

These mitochondrial morphological alterationsincluding reduced organelle size, increased membrane density, and cristae disruptionare established ultrastructural hallmarks of ferroptosis and are functionally associated with impaired mitochondrial bioenergetics, including loss of membrane potential, diminished electron transport chain activity, and excessive ROS generation (Figure 2G)