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According to one comprehensive analysis, knee OA has been sharply on the rise over the past three decades, with over 3 million cases reported world-wide in 2021, compared to only 1.4 million in 1990

These effects include energy metabolism, mitochondrial homeostasis, epigenetic regulation, endocrine regulation, inflammation and immune homeostasis, signal transduction, and neuromodulation (Fig

M1 macrophages exhibit a proinflammatory phenotype characterized by increased glycolysis and impaired mitochondrial OXPHOS