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Magnesium as a treatment was reported to considerably reduce insulin resistance and blood glucose levels, as well as attenuate renal hypertrophy and ameliorate associated inflammation in rats with DKD ( Magnesium is an essential mineral with multiple physiological functions and plays a potential role in mitigating oxidative stress, primarily by regulating various cellular and enzymatic processes in the antioxidant defense mechanism

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Importantly, NRF2 activation has been shown to alleviate PD-associated pathological hallmarks, specifically oxidative stress, mitochondrial dysfunction and neuroinflammation through expression of its target genes (Yang et al., 2022)

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