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The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

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In a review of studies, researchers found that while vitamin B12 supplementation did not improve depressive symptoms, low vitamin B12 levels were linked to an increased risk of developing depression

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