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The authors speculate that an alteration in the nanostructure of the mRNA-LLPs may have caused the low in vivo efficacy, as such a change could affect properties like the binding to serum proteins, which are absent in the in vitro study
Zller K, Haddadzadegan S, Lindner S, Veider F, Bernkop-Schnrch A
Retrieved May 6, 2025, from National Institutes of Health, Office of Dietary Supplements
RM-718, PL7737 and 710GO all report efficacy with acceptable nonclinical safety profiles, including no evidence of cardiac activation (130)
