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Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
Early inhibitors (hydroxycinnamate and lonidamine) lacked isoform selectivity, limiting their clinical potential (179,180)

10.1111/jcmm.18228 87 TangJ.SongX.ZhaoM.ChenH.WangY.ZhaoB.et al (2022)
Current research is extensively focusing on understanding the bioavailability and efficacy of these different delivery methods