glutathione synthetase assay (GSH & GSSG) Kit: 192 Tests | NWLSS The sample is first deproteinized with the 5% 5 Glutathione Synthetase - an overview

The key pathological hallmarks of AD include amyloid-beta (A) plaque accumulation, neurofibrillary tangles of hyperphosphorylated tau, chronic neuroinflammation, oxidative stress, and mitochondrial dysfunction (Lv et al., 2020)

One unit of Px equals the amount of enzyme that was needed to oxidise 1 mol of NADPH to NADP + per min at 25 C and pH 8.0

Reynolds GP

The datasets were all generated from the ROSMAP cohort, these included the single cell transcriptomic data from the prefrontal cortex region (snRNAseqPFC_BA10) (Syn18485175) 52 ( bulk RNA-seq data of dorsolateral prefrontal cortex (DLPFC), posterior cingulate gyrus (PCG), and anterior cingulate (AC) regions (syn3388564) 134 ( and the non-targeted metabolomics data form DLPFC region (syn3157322) ( Key clinical and pathological features of de-identified subjects included in these studies can be found in Supplementary Data 1

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