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Int J Mol Sci 12(5):31173132

Primary hippocampal neurons treated with -tocotrienol show a decrease in total and mitochondrial ROS accumulation, and -tocotrienol attenuates glutamate-induced post-translational cleavage of Bcl-xL to enhance the functions of antiapoptotic Bcl-xL [166,167]

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80 This idea could be supported by a recent systematic review which demonstrated an increase in TSH levels in concomitant use of levothyroxine and proton pump inhibitors (PPIs)

In 2023, the European Union established a mandatory upper limit of 800 mg/day for EGCG in dietary supplements, following safety evaluations that revealed transaminase elevations in nearly a quarter of intervention trials at doses 800 mg/day