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Researchers who have never used a GLP-1 agonist should generally start with tirzepatide or even semaglutide to understand their individual response to incretin therapy before attempting a triple agonist with higher side effect rates

JAMA 280 , 15961600 (1998)

Sudo K, Wang X, Xiao L, Wadhwa R, Shiozaki H, Elimova E, Rice DC, Lee JH, Weston B, Bhutani MS, Hiremath A, Charalampakis N, Komaki R, Blum MA, Swisher SG , Maru DM, Skinner HD, Garris JL, Rogers JE, Hofstetter WL, Ajani JA

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