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Its thought mainly to be caused by an autoimmune process that makes a person unable to produce a substance in the stomach called intrinsic factor
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Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

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Aye S, Johansson G, Hock C et al (2025) Point of view: challenges in implementation of new immunotherapies for Alzheimers disease