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However, under nutrient limitations or high energy demands, CIC shuttles citrate from the cytosol into mitochondria to support energy production through OXPHOS, thereby promoting cell survival

MansonJECookNRLeeI-MChristenWBassukSSMoraSet al

Some facilities use both approaches together for difficult wounds, though research on combined protocols is limited
Dysregulation in any of these regulatory nodes may induce ultrastructural mitochondrial abnormalities and functional impairments, ultimately precipitating axonal degeneration and neuronal apoptosispathological hallmarks that define neurodegenerative pathogenesis (Hong et al., 2024)

M., Reiss E., and Tyler F
