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Antiviral therapies, such as nucleos(t)ide analogs and interferons, can control viral replication but rarely cure the infection due to the persistence of HBV covalently closed circular DNA (cccDNA) ( While HBV alone can drive CHB, cirrhosis, and HCC, concurrent alcohol use accelerates liver damage, increases HBV persistence, and raises the risk of malignancy

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For a comprehensive discussion of this topic, please see Stockwell et al

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10.1016/j.celrep.2020.108466 [DOI] [PubMed] [Google Scholar] 35.Wu M, Lee MYY, Bahl V et al (2021) Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry