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Inflammatory response of disc cells against Propionibacterium acnes depends on the presence of lumbar Modic changes

One question is why GsMTx4 affects many key physiological processes in vitro , but has little effect on normal physiological processes in vivo , yet has a strong therapeutic effect on pathology

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Enzymes that consume NAD + generate NAM as a product, and this can be recycled in the salvage pathway, providing the primary NAD + synthesis pathway in mammals 30

doi:10.1016/j.arthro.2024.09.005