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Effects of Various Dietary Fats on Cardiolipin Acyl Composition during Ontogeny of Mice

Together with existing docking and pharmacological studies, these findings support a general pharmacophore in which a conserved basic center, C15/C20 hydrophobic substituents, and configuration-dependent orientation of the indole/oxindole core jointly dictate MOR affinity, subtype selectivity, and potentially signaling bias (Figure 11)

76,77 Proliferation of astrocytes is an indispensable part of reactive astrogliosis, and suppression of proliferation exacerbates damage and delays wound closure