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These included: Expressive communication Personal and domestic daily living skills Interpersonal skills Play-leisure skills Coping social skills Other clinical improvements observed with B12 included improvements in: Sleep Gastrointestinal symptoms Hyperactivity Tantrums Nonverbal intellectual quotient Vision Eye contact Echolalia Stereotypy Anemia Nocturnal enuresis (bed wetting) Adverse events with B12 identified by meta-analysis included: Hyperactivity (11.9%) Irritability (3.4%) Trouble sleeping (7.6%) Aggression (1.8%) Worsening behaviors (7.7%) But adverse effects were generally few, mild, not serious, and not significantly different compared to placebo

Microdosing tirzepatide is another approach where smaller, more frequent doses are used

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The global pathology Z-score represents a quantitative summary of A (neuritic and diffuse plaque) and tau burden across five brain regions: the midfrontal cortex, midtemporal cortex, inferior parietal cortex, entorhinal cortex, and hippocampus
