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Accessed 12 June 2025

M., Carter, D

The hallmarks of IVDD include a reduction in nucleus pulposus cells, degradation of the extracellular matrix (ECM), activation of an inflammatory microenvironment, and loss of biomechanical function, accompanied by structural changes such as annulus fibrosus rupture, nucleus pulposus dehydration, and endplate calcification (Zhu et al., 2023

Purity is non-negotiable
Pharmaceuticals 17, 361