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A novel study that utilized human glial cell-derived neurotrophic factor (GDNF) gene and a neurotensin polyplex nanoparticle vector in an animal model of PD found that a single intracerebral injection of the non-viral agent may be able to activate a biochemical and functional response, suggesting that this method may still be effective, regardless of the latter concerns [89]

In one small study, Epitalon significantly stimulated evening melatonin synthesis in senescent rhesus monkeys (Macaca mulatta) and helped normalize their circadian cortisol rhythm

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