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Outline how oxidative glucose metabolism and the pentose phosphate pathway are regulated to balance energy needs and NADPH production MODES OF OPERATION OF THE PATHWAY The pentose phosphate pathway can operate in several modes, depending on the needs of the cell

Cytosol and nucleus Although antioxidant systems keep basal ROS low, key cytosolic/nuclear enzymes generate localized signals

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Oostwoud LC, Gunasinghe P, Seow HJ, et al
