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Almost none have completed the large, long-term human trials that would tell us whether theyre safe to use for months or years

NAD+ therapy should be administered under the guidance of a qualified physician

Dogs that might benefit from Vitamin B12 supplementation: If your dog has any of the following, your veterinarian might suggest vitamin B12 supplements: Inflammatory bowel disease (IBD) Exocrine pancreatic insufficiency (EPI) Small intestinal bacterial overgrowth (SIBO) Short bowel from bowel surgery Malignant tumor of the intestine

Shaking creates air bubbles and can cause protein aggregation effectively denaturing the peptide at the foam interface

(Supplementary Figure 4.1)