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10.1007/s11655-017-2906-x 21 GuY

[45] reported an epigenetic regulation system based on exosomal CRISPR intervention (RVG-CRISPRi-Exo), which consisted of exosome membranes encapsulating sgRNA targeting specific regions of the CpG island (CGI) in the murine SNCA gene, the dCas9-DNMT3A fusion protein, and RVG-Lamp2b, for PD treatment (Fig

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