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Thus, similar to peroxide-mediated inactivation of GPx-1, the in vivo role of RNS-mediated pathways of GPx-1 inactivation may depend on the overall intracellular redox environment, including concentrations of GSH, the ratio of GSH/GSSG, and the amount of RNS produced

Therefore, the above results suggested that ATF4 could suppress HuOCSC ferroptosis

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