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2mg of copper

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In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

The literature suggests that anything from 10% to 30% of those prescribed prolonged metformin experience malabsorption of vitamin B 12, with 69% of individuals shown to progress to deficiency