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There is no established upper limit for B12 intake due to its low risk of toxicity

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However, in another study, IGF-mediated stimulation of progesterone synthesis and secretion in human ovarian cells is dependent on MAPK/ERK1/2 and p38 MAPK signaling (127)

Blood (2018) 131(23):258193

10.1016/j.cell.2018.03.035
