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The glucagon-like peptide-1 agonists (GLP-1s) class of weight-loss drugs, which includes medications like tirzepatide and semaglutide, have been shown to reduce body fat in large clinical trials

In transected rat Achilles tendon models, BPC-157 treatment resulted in accelerated recovery with increased load to failure, superior functional scores, enhanced cellular infiltration for repair, better collagen fiber organization, and smaller persistent defects compared to untreated controls

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However, due to age-related immunosenescence and the capability of senescent cells to evade immune surveillance, senescent cells are spared and accumulate in diverse tissues (75)