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When comparing the responders from the CRWP group ( n = 12) to the non-responders in the same group ( n = 7), there was a significant difference in age with the responders being significantly older (4.23 0.22 years) than non-responders (3.48 0.18 years
10.1016/j.carres.2020.107958 85 WangL.YuanQ.MarshallG.CuiX.ChengL.LiY.et al (2010)
Clinical observations support this paradigm that strategic drug holidays, which exploit ERK hyperactivation-mediated growth constraints, may delay progression in TKI-tolerant patients
EMBO Rep 2019;20:e47903
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