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Cluster analysis (Figure S5B) demonstrated clear separation between groups: controls clustered with high Bacteroidota/Actinomycetota representation, ASD models formed a distinct Firmicutes-dominated cluster, and hCiPSCs-treated animals occupied an intermediate position

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The results demonstrated that C35, shown in the Figure 5 below, can inhibit the catalytic activities of both TET1 and TET3 with IC50 values of 3.48 M and 2.31 M, respectively

Ramautar R, Berger R, van der Greef J, Hankemeier T (2013) Human metabolomics: strategies to understand biology

Science 253:12801283 Ohta K, Makinen KK, Loesche WJ (1986) Purification and characterization of an enzyme produced by Treponema denticola capable of hydrolyzing synthetic trypsin substrates