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These cristae dramatically increase the surface area available for oxidative phosphorylation, the major metabolic process responsible for ATP synthesis

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Mechanism-based treatments Mechanism-based treatments aim to target the underlying pathophysiological processes of DN to alleviate symptoms and prevent disease progression

High doses too frequently may lead to rare side effects like low potassium or vascular stress

Tirzepatide (Zepbound/Mounjaro) is a GLP-1 receptor agonist, but it also is a GIP receptor agonist, so it has an additional mechanism of action