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While the molecular pathogenesis of AxD remains incompletely understood, massive reactive astrogliosis with Rosenthal fibers composed of aggregated GFAP, vimentin, nestin, B-crystallin and small heatshock proteins together with prominent leukodystrophy are the pathological hallmarks, with the pathophysiological picture including mitochondrial malfunction, redox imbalance and susceptibility to oxidative stress 331,332,333

The processing model proposes that LYSET acts as a bridge between S1P and GNPT to enhance the cleavage of the latter

During the catastrophic hemorrhage that occurs during the late phase of Ebola virus infection, melatonin plays a crucial role in preserving the integrity of the blood vessels and shielding endothelial cells from damage (31,75,78,82,83)

doi: 10.1152/ajprenal.00026.2024 185

Human evidence: Very limited, older clinical observations in specific patient groups