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To understand the structural basis of this abnormal binding characteristic, Sack et al solved the crystal structure of the wild-type (WT) (PDB: 1I37) and T877A (PDB: 1I38) AR LBDs complexed with DHT 67

MDA and other TBARS react with two equivalents of TBA, resulting in a fluorescent red derivative detectable spectrophotometrically (Nair, O'Neil, and Wang, 2008)

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