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Nasal administration of a temozolomide-loaded thermoresponsive nanoemulsion reduces tumor growth in a preclinical glioblastoma model

EF, ejection fraction

Experimental studies increasingly suggest that curcumin-piperine combinations may exert synergistic neuroprotective effects by simultaneously targeting oxidative stress, neuroinflammation, mitochondrial dysfunction, and protein aggregation pathways (Banji et al., 2013

274,275 Therapeutic strategies targeting oxidative stress and mitochondrial dysfunction include using antioxidants like alpha-lipoic acid (ALA), which improves neuropathic symptoms and nerve conduction velocities in patients with DPN

Therefore, it is important to understand the pathways of human exposure to MPs which include ingestion, inhalation, and skin contact as the common ways ( Figure 1 )