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These crucial intermediates (fatty acyl-CoA thioesters) undergo metabolism through mitochondrial -oxidation pathways, which involve a series of enzymes located either in the inner mitochondrial membrane or mitochondrial matrix (Fig

Since then, more than 80 others have hit the market, used to treat conditions including cancer, osteoporosis, multiple sclerosis, HIV, and chronic pain

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They might be isolated, but in 85% of the cases, GCDs are associated with concomitant diverticular disease