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Another limitation to the study is the use of subjective and informant-based instruments (SRS, ABC, SEC, CGI) due to the lack of reliable and readily available objective or performance-based instruments to measure the clinical severity of ASD and treatment outcomes

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In the PANTHEON study, 6 146 out of 495 (29%) in the NAC group showed mild side effects, not different from the control group (130 out of 495, 26%)

A more recent hypothesis postulates that high-dose folic acid redirects the active form of vitamin B12 in serum, i.e., holotranscobalamin, either toward the bone marrow to support reticulocyte synthesis that is induced by folic acid in B12-deficient patients, or into the urine in which it is excreted instead of being taken up and recycled into circulation through the kidneys (84)

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