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Meanwhile, CoQ10-FSP1 axis is a key downstream effector of Keap1-Nrf2 pathway (Koppula et al., 2022)
Consequently, therapeutic strategies targeting inflammatory pathways demonstrate dual efficacy of attenuating chronic tissue damage that predisposes to malignant transformation and disrupting pro-tumorigenic cytokine networks within TME ( 3.4.1 Inflammatory cytokine modulation Immunomodulatory constituents enhance innate immune surveillance
In addition, CBD improved the left ventricular function and protected against reperfusion injury, which was associated with reduced leukocyte infiltration in the heart [116]
EGCG inhibits the transpiration of VEGF by inducing apoptosis and negatively modulates metastasis
doi:10.3389/fonc.2021.696702
