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At the post-translational level, just as CBP/p300-mediated acetylation of Lys within the Neh1 domain increasing NRF2-dependent transcription, SIRT1 mediates Lys deacetylation, antagonizing the NRF2 signal [234]

Sun M, Zigman S

Ding L, Zhang FB, Liu H, Gao X, Bi HC, Huang L, et al

PubMed, Bhandage, Amol K., and Antonio Barragan

Unlike artificial sweeteners like aspartame or sucralose, which are created in a lab, stevia starts as a plant
